Journal article
Postprandial effects of a high salt meal on serum sodium, arterial stiffness, markers of nitric oxide production and markers of endothelial function
KM Dickinson, PM Clifton, LM Burrell, PHR Barrett, JB Keogh
Atherosclerosis | Published : 2014
Abstract
Aim: The aim of the study was to determine if a high salt meal containing 65mmol Na causes a rise in sodium concentrations and a reduction in plasma nitrate/nitrite concentrations (an index of nitric oxide production). Secondary aims were to determine the effects of a high salt meal on augmentation index (AIx) a measure of arterial stiffness and markers of endothelial function. Methods and results: In a randomised cross-over study 16 healthy normotensive adults consumed a low sodium soup containing 5mmol Na and a high sodium soup containing 65mmol Na. Sodium, plasma nitrate/nitrite, endothelin-1 (ET-1), C-reactive protein (CRP), vasopressin (AVP) and atrial natriuretic peptide (ANP) concentr..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
[ "Supported by the Commonwealth Scientific and Industrial Research Organisation (CSIRO) and the National Health and Medical Research Council (NHMRC) grants (44102557) (1004380) (990156) (566947).", "KMD is supported by Postgraduate Scholarships from the Faculty of Health Science, University of Adelaide and the (CSIRO).", "PHRB is a NHMRC Senior Research Fellow; PMC is a NHMRC Principal Research Fellow, JBK is supported by a South Australian Cardiovascular Research Development Program Research Fellowship." ]